ncRNA name | PDGF-CC shRNA |
ncRNA Category | shRNA |
Disease name | choroidal neovascularization (CNV) |
Species | Mus musculus |
Tissues/Cell_line | retinas and choroids |
Methods | shRNA knockdown, IB4 or H&E staining, fluorescein angiography, qPCR, Western blot |
Expression pattern | associated |
Functional description | Treatment with PDGF-CC shRNA, which reduced the PDGF-CC expression level to approximately 40% of normal level, reduced CNV area 7 d after laser treatment when injected into vitreous or subretinal space. |
PubMed ID | 20566880 |
Year | 2010 |
Title | PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets. |
Drug-related ncRNA | NA |
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